Research

Brain: Stroke Recovery

Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells
Neurology, 2018
LASER therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells
These findings provide strong support for the promising therapeutic effect of lasers on:

  • Neuronal repair following ischemic stroke
  • Decreasing inflammatory status and promoting mitochondrial function
ncbi.nlm.nih.gov
Photobiomodulation Laser for Traumatic Brain Injury and Stroke
Neurosci Res, 2018
There is evidence that Laser Therapy can help the brain repair itself by stimulating neurogenesis, upregulating BDNF synthesis, and encouraging synaptogenesis. In healthy human volunteers (including students and healthy elderly women), Laser Therapy has been shown to:

  • Increase regional cerebral blood flow
  • Increased tissue oxygenation
  • Improved memory, mood, and cognitive function
  • Clinical studies have been conducted in patients suffering from the chronic effects of TBI. There have been reports showing improvement in executive function, working memory, and sleep. Functional magnetic resonance imaging has shown modulation of activation in intrinsic brain networks likely to be damaged in TBI (default mode network and salience network)
ncbi.nlm.nih.gov
Transcranial Low-level Laser Therapy may Improve Alertness and Awareness in Traumatic Brain Injured Subjects with Severe Disorders of Consciousness: A Case Series
Journal Neurology and Neuroscience, 2015
Transcranial [Through the skull] low-level laser therapy (T-LLT) proved promising in acute stroke studies and in single traumatic brain injured subjects (TBI). It was assumed to increase cortical mitochondrial energy production and/or vasodilatation.

  • Coma Recovery Scale… improved in all patients during the intervention. Follow-up revealed a sustained effect
  • The patient in the state of akinetic mutism improved her competence in the activities of daily living and mobility status. Single epileptic fits occurred in two patients during the intervention
jneuro.com
Infrared laser therapy for ischemic stroke: a new treatment strategy
Stroke, 2007
Double-blind trial involving 120 ischemic stroke patients treated. Infrared laser therapy has shown initial safety and effectiveness for the treatment of ischemic stroke in humans when initiated within 24 hours of stroke onset.
ncbi.nlm.nih.gov
Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits
Stroke, 2006
The number of newly formed neuronal cells… as well as migrating cells was significantly elevated in the subventricular zone of the hemisphere ipsilateral to the induction of stroke when treated by LLLT.

CONCLUSIONS: Our data suggest that a noninvasive intervention of Laser issued 24 hours after acute stroke may provide a significant functional benefit with an underlying mechanism possibly being induction of neurogenesis.

ncbi.nlm.nih.gov

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