Research

Brain: Neurodegenerative Conditions (Alzheimer’s / Parkinson’s etc)

Lasers and Neurodegenerative Conditions (Dementia / Parkinsons)

Many of the world’s top medical universities, medical journals, and researchers are publishing studies which conclude that Low Level LASER Therapy is extremely beneficial for Neurodegernerative conditions. This list includes studies for Alzheimer’s and Parkinson’s disease, among other types of Neurodegenerative disease.

Summary of research findings:

  • NeuroGenesis (Stimulates new neurons to form!)
  • Increases ATP production (Stimulates cellular energy to flood out of the cell)
  • Decreases Brain Plaque (amyloid-β etc)
  • Reverses Hypoxia damage (increases oxygen circulation and uptake into brain cells)
  • Improves Memory
  • Slows/reverses Aging process
  • Decreases anxiety due to cognitive decline
  • Suppresses oxidative stress
  • Suppresses inflammatory cascade
  • Induces brain wave that your doctor pre-selects. (Immediate and accurate brain changes)

Watch this landmark 2017 study published by Harvard Medical School and Boston University School of Medicine’s Department of Nerology demonstrate how lasers improve brain wave function, cognition, and memory in Alzheimer’s patients:

LED headset shows promise for Alzheimer’s, brain injuries

The entire Harvard study and its jaw-dropping conclusions can be seen here.

Treating cognitive impairment with transcranial low level laser therapy
Journal of Photochemistry and Photobiology B: Biology, 2017
Boosting brain activity through non-invasive transcranial laser biostimulation of neuronal mitochondria may be a valuable tool in:

  • Preventing or delaying age-related cognitive decline that can lead to dementia, including its two major subtypes, Alzheimer’s and vascular dementia
  • The technology to achieve significant improvement of cognitive dysfunction using [LASER therapy] or variations of this technique is moving fast and may signal a new chapter in the treatment and prevention of neurocognitive disorders
  • Raises neurometabolic energy levels that can improve cerebral hemodynamics [blood flow, Cerebral Spinal Fluid flow, lymph flow] and cognitive abilities in humans

“Growing evidence that neurodegenerative damage and cognitive impairment during advanced aging is accelerated or triggered by a neuronal energy crisis generated by brain hypoperfusion. We have previously proposed that chronic brain hypoperfusion in the elderly can worsen in the presence of: vascular risk factors = hypertension, cardiac disease, atherosclerosis and diabetes type 2.”

ncbi.nlm.nih.gov
670 nm laser light and EGCG complementarily reduce amyloid-β aggregates in human neuroblastoma cells: basis for treatment of Alzheimer's disease?
J Neuroinflammation, 2012
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases. There was a significant increase in cell numbers in response to laser irradiation. Laser irradiation significantly increased ATP levels in Aβ(42)-free cells.
ncbi.nlm.nih.gov
Neuroscience, 2010
Our data showed that laser light at 632.8 nm suppressed Aβ-induced superoxide production, colocalization between NADPH oxidase gp91(phox) and p47(phox) subunits, phosphorylation of cPLA(2,) and the expressions of IL-1β and iNOS in primary astrocytes. We demonstrated for the first time that 632.8 nm laser was capable of suppressing cellular pathways of oxidative stress and inflammatory responses critical in the pathogenesis in Alzheimer’s Disease (AD). This study should prove to provide the groundwork for further investigations for the potential use of laser therapy as a treatment for AD.
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
Neuroscience, 2008
These results strongly suggest that LED treatment may be therapeutic to neurons damaged by neurotoxins linked to Parkinson’s disease by energizing the cells and increasing their viability.
ncbi.nlm.nih.gov
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease
Front Neurosci, 2016
Alzheimer’s and Parkinson’s develop after a progressive death of many neurons in the brain. Red to infrared light therapy (λ = 600-1070 nm), and in particular light in the near infrared (NIr) range, is emerging as a safe and effective therapy that is capable of arresting neuronal death. Previous studies have used NIr to treat tissue stressed by hypoxia, toxic insult, genetic mutation and mitochondrial dysfunction with much success. Here we propose LASER therapy as a neuroprotective or disease-modifying treatment for Alzheimer’s and Parkinson’s patients.
ncbi.nlm.nih.gov
Turning On Lights to Stop Neurodegeneration: The Potential of Near Infrared Light Therapy in Alzheimer's and Parkinson's Disease
Frontiers in neuroscience, 2015
Near Infrared (NIr) LASER has the potential to be neuroprotective. A growing body of pre-clinical evidence indicates that NIr therapy slows or stops disease pathology. This is something that the current mainstay of treatments for both diseases—drug therapy—does not do. Although in its infancy, with the bulk of results still at the pre-clinical “proof of concept” stage, NIr therapy has the potential to develop into a safe and effective neuroprotective treatment for patients with Alzheimer’s and Parkinson’s disease (and presumably other neurodegenerative diseases such multiple sclerosis and amyotrophic lateral sclerosis).
ncbi.nlm.nih.gov
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson's disease
Parkinsonism Relat Disord, 2012
Photobiomodulation enhances nigral dopaminergic cell survival in a chronic MPTP mouse model of Parkinson’s disease. “We have shown previously that photobiomodulation or near-infrared light (NIr) treatment protects dopaminergic cells of the substantia nigra pars compacta (SNc).. model of Parkinson’s disease (PD). In this study, we tested the protective and rescue action of NIr treatment in a chronic MPTP model. In summary, exposure to NIr either at the same time or well after chronic induced parkinson’s disease saved many Substantia Nigra dopaminergic cells from degeneration.”
ncbi.nlm.nih.gov
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models
Alzheimer's Research & Therapy, 2014
Potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations. NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.
ncbi.nlm.nih.gov
Low-level light therapy of the eye and brain
Eye Brain, 2011
Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Since mitochondrial dysfunction plays a key role in neurodegeneration, LLLT has potential significant applications against retinal and brain damage by counteracting the consequences of mitochondrial failure. Upon transcranial delivery in vivo, LLLT induces brain metabolic and antioxidant beneficial effects, as measured by increases in cytochrome oxidase and superoxide dismutase activities. Increases in cerebral blood flow and cognitive functions induced by LLLT have also been observed in humans. Importantly, LLLT given at energy densities that exert beneficial effects does not induce adverse effects. This highlights the value of LLLT as a novel paradigm to treat visual, neurological, and psychological conditions, and supports that neuronal energy metabolism could constitute a major target for neurotherapeutics of the eye and brain.
ncbi.nlm.nih.gov
Unique visual stimulation may be new treatment for Alzheimer’s
MIT, 2016
Using LED lights flickering at a specific frequency, MIT researchers have shown that they can substantially reduce the beta amyloid plaques seen in Alzheimer’s disease, in the visual cortex of mice… Previous studies have hinted that Alzheimer’s patients also have impaired gamma oscillations. These brain waves, which range from 25 to 80 hertz (cycles per second), are believed to contribute to normal brain functions such as attention, perception, and memory. After an hour of stimulation at 40 hertz, the researchers found a 40 to 50 percent reduction in the levels of beta amyloid proteins in the hippocampus. Stimulation at other frequencies, ranging from 20 to 80 hertz, did not produce this decline.
news.mit.edu
Toward Treating Alzheimer’s Disease with Brain Waves
Picower Institute for Learning and Memory, 2016
Disruption of gamma waves could be a key contributor to Alzheimer’s disease pathology, according to a mouse study published today (December 7) in Nature. Stimulation of gamma waves reduced levels of amyloid-β, decreased phosphorylation of tau, and led the brain’s immune cells—microglia—to perform their usual housekeeping role, clearing away cellular debris, including amyloid-β (as opposed mounting an inflammatory response as microglia do in Alzheimer’s disease).
the-scientist.com
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Nature volume 540, pages 230–235, 2016
nature.com
Low-Level Laser Therapy Rescues Dendrite Atrophy via Upregulating BDNF Expression: Implications for Alzheimer's Disease
Journal of Alzheimer's Disease, 2011
In this study, after confirming the prosurvival effect of 633 nm LLLT on Aβ25–35-treated primary hippocampal neurons in a dose–response manner (Fig. 1), we found similar effect of LLLT on Aβ1–42-treated hippocampal neurons as well. Administration of TLT transcranial laser therapy was associated with a dose-dependent reduction in amyloid load. All TLT doses mitigated the behavioral effects seen with advanced amyloid deposition and reduce the expression of inflammatory markers in the AβPP transgenic mice. All TLT doses produced an increase in sAβPPα and a decrease in CTFβ levels consistent with inhibition of the β-secretase activity. In addition, TLT showed an increase in ATP levels, mitochondrial function, and c-fos suggesting an overall improvement in neurological function. These studies suggest that TLT is a potential candidate for treatment of AD.
jneurosci.org
Neuroprotective Effects of Near-Infrared Light in an In Vivo Model of Mitochondrial Optic Neuropathy
Journal of Neuroscience, 2008
Julio C. Rojas: evidence that NIL treatment via light-emitting diodes exerts neuroprotective effects against rotenone-induced neurotoxicity in vivo. These neuroprotective effects were observed at the behavioral, morphologic and neurochemical levels in a dose–response manner. These results add to a large body of compelling evidence suggesting that the biological effects of NIL laser therapy could be effectively used to treat neurodegenerative conditions.
jneurosci.org

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